Custom Synthesis Services Quotation Form

Custom synthesis with tritium

Custom synthesis of non-labeled compounds

Custom synthesis with stable isotopes, carbon-13, nitrogen-15 and deuterium

Oligonucleotide custom synthesis with tritium, carbon-14 or sulphur-35

Guaranteed Custom Synthesis with Tritium - Quotation Form

The tritium custom synthesis offered by MB is designed to minimize uncertainty about the outcome of a project. A detailed quotation is used to outline the specifications of the final product before work is started. The compound will meet the agreed upon specifications for minimum specific activity, total activity, and purity (usually 97% by HPLC) or no fee is charged.

A variety of labeling techniques and synthetic procedures are used to efficiently tritiate even relatively unstable biochemicals.

Tritium custom synthesis includes the following:

Performance of the labeling procedure and / or synthesis
Purification by paper, thin layer, or high performance liquid chromatography
Determination of the final product's purity, specific activity, and total activity
Documentation of the final product's purity, specific activity, and total activity in a product data sheet

Custom Synthesis with Carbon-14 - Quotation Form

MB has a long standing record of accomplishments in the multiple step preparation of carbon-14 organic molecules. Over the past 35 years our staff has aquired considerable expertise in radiosynthesis of carbon-14 labeled biochemicals, pharmaceuticals, agrochemicals, polymers, dyes, and organic reagents.

Carbon-14 custom synthesis includes the following:

Performance of the synthesis as outlined in our quotation
Purification by paper, thin layer, or high performance liquid chromatography
Determination of the final product's purity, specific activity, and total activity
Documentation of the final product's purity, specific activity, and total activity in a Product Data Sheet

Custom Synthesis of Non-labeled Compounds - Quotation Form

Our synthetic team has acquired extensive experience in the multi-step preparation of nucleosides, nucleotides and a variety of other complex organic molecules. Over the past 35 years our staff has successfully prepared hundreds of biochemicals, pharmaceuticals, agrochemicals, polymers, dyes and organic reagents.

Custom Synthesis with Sulphur-35 - Quotation Form

A variety of techniques are used including a sulphur-35 labeling method developed by MB scientists to efficiently label Thiopurines and Thiopyrimidines up to nucleotide level.

Sulphur-35 [³⁵S] custom synthesis includes the following:

Performance of the synthesis as outlined in our quotation
Purification by paper, thin layer or high performance liquid chromatography
Determination of the final product's purity, specific activity and total activity
Documentation of the final product's identity, purity, specific activity and total activity

Custom synthesis with stable isotopes, carbon-13, nitrogen-15 and deuterium - Quotation Form

Extensive experience in preparation of nucleic acid components and their analogs makes our efficient custom stable isotope synthesis the right choice.

Stable isotope custom synthesis includes:

Performance of the synthesis as outlined in our quotation
Purification by paper, thin layer or high performance liquid chromatography
Determination of the final product's chemical purity
Documentation of the final product's identity, chemical purity and isotopic enrichment

Oligonucleotide Custom Synthesis with Tritium, Carbon-14 or Sulphur-35 - Quotation Form

Labeling of phosphodiester phosphorothioate oligonucleotides with phosphoramidites of DMT-Td, [4,6-¹⁴C]- or DMT-Td, [methyl-³H]- incorporated in specific position during synthesis
High molar specific radioactivity (100μCi for each μmol of Td, [4,6-¹⁴C]- incorporated or up to 3mCi for each μmol of Td, [methyl-³H]- incorporated)
Multiple position labeling and multiple isotope labeling available
Radiosulfur labeling in specific position (single or multiple) of phosphorothioate oligonucleotides, to incorporate up to 500 μCi of ³⁵S for each μmol of nucleotide labeled
Purification by HPLC